ATLANTA (September 7, 2017) – The National Institutes of Health (NIH) has renewed the designation of Marcus Autism Center as a national Autism Center of Excellence (ACE), with funding from 2017 to 2022. The ACE designation supports large-scale multidisciplinary studies on autism spectrum disorder (ASD), with the goal of identifying causes and best treatments for autism.
As one of only five centers to receive this designation, Marcus Autism Center will receive $11.25 million through a five-year grant. It is the most prestigious recognition in autism research – across the country and in the world.
"The renewal of our ACE award, which we first received in 2012, is an acknowledgment from the NIH of the groundbreaking results achieved by our dedicated research and clinical teams over the first five years of our ACE program," says Ami Klin, PhD, Director of Marcus Autism Center, a Georgia Research Alliance Eminent Scholar and Professor of Pediatrics in Emory University School of Medicine.
"Our success in delineating the genetic, neural and behavioral mechanisms of autism, the promise of future discoveries that can positively impact the lives of children and their families, and this designation and support from the NIH would not be possible without the unique partnership among Marcus Autism Center, Emory University School of Medicine and Children's Healthcare of Atlanta," says Klin. "We also owe our success to the strong support of community members such as Bernie Marcus and the Marcus Foundation, the Whitehead Foundation and the Georgia Research Alliance."
Through pioneering research in the first five years of the ACE designation, investigators at Marcus Autism Center and Emory University School of Medicine have shown that developmental deviations in social communication can be identified as early as two months old, well before reliable clinical diagnoses of autism. These findings resulted from a robust research program including Emory University School of Medicine, Yerkes National Primate Research Center, Florida State University, and collaborators across the United States. For example, their July 2017 publication in the journal Nature demonstrated that these developmental deviations are under genetic control, bridging molecular studies to behavior.
"Our goal is to change the narrative of autism from one of potentially devastating disability to one of positive diversity, in which individuals with autism are able to succeed despite their learning differences and because of their unique assets," says Dr. Klin. "We believe the scientific work funded by this grant will have the power to favorably disrupt the current state of early detection and intervention in autism, and has the power to achieve improvements in developmental trajectories with lifelong implications."
Over the next five years, our team will study the development of both brain and behavior in 250 human infants and 15 infant monkeys. The projects span from genes to neighborhoods, and aim to generate new scientific discoveries, ultimately leading to a new community-based system of healthcare delivery for infants and toddlers with autism and their families.
The five individual research projects included in the ACE grant are as follows:
- Project 2: Spoken communication between infants and caregivers
Five years of research in the first ACE grant provided compelling evidence for a causal link between early deficits in social engagement and later deficits in speech and language in infants at risk of autism. This project reaches across every stage of vocal development, beginning in the first months of life, and includes developmental progressions in vocal behavior in both infants and caregivers that are disrupted in autism. A team led by Gordon Ramsay and Ami Klin will continue research into treatments targeting social interactions between infants and caregivers that could more effectively promote speech development than treatments targeting speech development in the infant alone.
- Project 3: Neuroimaging of infant brain development
Investigators Sarah Shultz, Warren Jones, and Longchuan Li will map transitions in brain and behavior over the first six months of life in infants at high- and low-risk for autism. The study builds on earlier results showing that looking at the eyes of others is already in decline in the first six months of life in infants with autism. The investigators will further explore the mechanisms behind findings that infants with autism exhibit a slight increase in eye-movement at two months that later declines, meaning reflex-like predispositions for looking may be initially present but are not integrated into social interaction as the brain matures.
- Project 4: New treatment models for infants
Using innovative web-based technology, researchers, led by Amy Wetherby, will teach parents to identify early social communications milestones and support their children's early development through a behavioral intervention. The results will be measured to identify and optimize opportunities for learning and to improve outcomes.
- Project 5: Model system of social behavior
Investigators Jocelyne Bachevalier, Warren Jones, and Mar Sanchez will conduct research with nonhuman primate infants living with their mothers in social groups at the Yerkes National Primate Research Center Field Station. Studies based on earlier ACE research will include behavioral and neural measures similar to those used in human infants to characterize social visual engagement and neuromotor development, including a focus on mother-infant reciprocal behaviors. The studies will help with assessment of how genetic variations alter social development and evaluation of potential therapeutic treatments.
The ACE grant also will promote education and training to disseminate best practices to primary care providers and to present relevant and empowering information to affected families and the community at large.
Marcus Autism Center
Marcus Autism Center is a not-for-profit organization and an affiliate of Children’s Healthcare of Atlanta that treats more than 5,500 children with autism and related disorders a year. As one of the largest autism centers in the U.S. and one of only three National Institutes of Health Autism Centers of Excellence, Marcus Autism Center offers families access to the latest research, comprehensive evaluations and intensive behavior treatments. With the help of research grants, community support and government funding, Marcus Autism Center aims to maximize the potential of children with autism today and transform the very nature of autism for future generations.
Emory University School of Medicine Department of Pediatrics
Faculty-physicians in the Emory Department of Pediatrics provide the highest quality state-of-the-art clinical care, with a commitment to improving treatment for children through scientific research as well as training the next generation of leaders in pediatrics.
Children’s Healthcare of Atlanta/Marcus Autism Center